Laboratory for Cardiovascular Engineering & Therapeutics

1. Lee J, Ochoa M, Henderson K, Maceda P, Yoon E, Samarneh L, Wong M, and Baker AB. High Throughput Mechanobiological Screens For Enhancing Pluripotency Markers in Mouse Embryonic Fibroblasts (Preprint; BIORXIV/2018/480517)

2. Sligar AD*, Howe G*, Goldman J, Felli P, Karanam V, Smalling RW, and Baker AB. Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits (in press at the Journal of Visualized Experiments).

3. Patil N, Le C, Sligar AD, Mei L, Chavarria, Yang EY, and Baker AB. Algal Polysaccharides as Therapeutic Agents for Atherosclerosis. Frontiers in Cardiovascular Medicine, 5, 153, 2018.

4. Veith AP, Henderson K, Spencer A, Sligar AD, and Baker AB. Therapeutic Strategies for Enhancing Angiogenesis in Wound Healing. Adv Drug Deliv Rev, 2018 (IF = 15.606).

5. Potter S, Graves J, Drach B, Leahy T, Hammel C, Feng A, Baker AB, and Sacks MS, A Novel Small-Specimen Planar Biaxial Testing System with Full In-Plane Deformation Control. J Biomech Eng, 2017 (accepted; IF = 2.057).

6. Le V, Lee J, Chaterji S, Spencer A, Liu YL, Kim P, Yeh HC, Kim DH, Baker AB. Syndecan-1 in mechanosensing of nanotopological cues in engineered materials. Biomaterials. 2017 Nov 9. doi: 10.1016/j.biomaterials.2017.11.007.

7. Henderson K, Sligar AD, Le VP, Lee J, Baker AB. Biomechanical Regulation of Mesenchymal Stem Cells for Cardiovascular Tissue Engineering. Adv Healthc Mater. 2017 Sep 25. doi: 10.1002/adhm.201700556. Review.

8. Monteforte A, Lam B, Sherman MB, Henderson K, Sligar A, Spencer A, Tang B, Dunn A, Baker AB. Glioblastoma Exosomes for Therapeutic Angiogenesis in Peripheral Ischemia. Tissue Eng Part A. 2017 Jul 12. doi: 10.1089/ten.TEA.2016.0508. [Epub ahead of print]

9. Hsieh P-L, Rybalko V, Baker AB, Suggs LJ, Farrar RP. Recruitment and therapeutic application of macrophages in skeletal muscles following hind-limb ischemia. Journal of Vascular Surgery, 2017.

10. Das S, Baker AB. Biomaterials and Nanotherapeutics for enhancing Skin wound Healing. Frontiers in Bioengineering and Biotechnology. 2016;4.

11. Das S, Majid M, Baker AB. Syndecan-4 Enhances PDGF-BB Activity in Diabetic Wound Healing. Acta Biomater. July 2016 (IF = 6.025).

12. Das S, Singh G, Majid M, Sherman MS, Mukhopadhyay S, Wright CS, Martin PE, Dunn AK and Baker AB. Syndesome Therapeutics for Enhancing Wound Healing in Diabetes. Adv Healthc Mater. July 2016 (IF = 5.797).

13. Monteforte AJ, Lam B, Das S, Mukhopadhyay S, Wright CS, Martin PE, Dunn AK, Baker AB. Glypican-1 nanoliposomes for potentiating growth factor activity in therapeutic angiogenesis. Biomaterials 94:45-56, July 2016 (IF = 8.557).

14. Indolfi L, Ligorio M, Ting DT, Xega K, Tzafriri AR, Bersani F, Aceto N, Thapar V, Fuchs BC, Deshpande V, Baker AB, Ferrone CR, Haber DA, Langer R, Clark JW, Edelman ER. A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma. Biomaterials 93:71-82, July 2016 (IF = 8.557).

15. Das S, Monteforte AJ, Singh G, Majid M, Sherman MB, Dunn AK and Baker AB. Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes. Adv Healthc Mater 5(9):1008-13, May 2016 (IF = 5.797).

16. Spencer A and Baker AB, High Throughput Label Free Measurement of Cancer Cell Adhesion Kinetics Under Hemodynamic Flow. Scientific Reports 6, doi:10.1038/srep19854, 2016 (IF = 5.578).

17. Das S, Singh G, Monteforte A, Majid M, Sherman MB, Dunn AK, Baker AB. Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes. Advanced Healthcare Materials. Jan 2016. (5.797).

18. Spencer A, Spruell C, Nandi S, Wong M, Creixell M, Baker AB: A High-Throughput Mechanofluidic Screening Platform for Investigating Tumor Cell Adhesion During Metastasis. Lab on a Chip. Nov 2015. [Epub ahead of print, doi: 10.1039/c5lc00994d PMID: 25844518] (IF = 6.115).

    

19. Tu C, Das S, Baker AB: Nanoscale Strategies: Treatment for Peripheral Vascular Disease and Critical Limb Ischemia. American Chemical Society Nano, Apr 2015. [Epub ahead of print, PMID: 25844518] (IF = 12.033).

    

20. Lee J, Baker AB: Computational analysis of fluid flow within a device for applying biaxial strain to cultured cells. Journal of Biomechanical Engineering, 137(5):051006, May 2015. Doi: 10.1115/1.4029638. Epub 2015 Mar 5. (IF = 3.929).

    

21. Le V, Johnson CG, Lee JD, Baker AB: Murine model of femoral artery wire injury with implantation of a perivascular drug delivery patch. Journal of Visualized Experiments, Feb 2015. doi: 10.3791/52403. (IF = 1.19).

22. Chaterji S, Kim P, Choe SH, Tsui JH, Lam CH, Ho DS, Baker AB, Kim DH: Synergistic effects of matrix nanotopography and stiffness on vascular smooth muscle cell function. Tissue Engineering, Part A, 20(15-16):2115-26, Aug 2014. doi: 10.1089/ten.tea.2013.0455. Epub 2014 Apr 2 (IF = 4.64).

    

23. Chaterji S, Lam CH, Ho DS, Proske DC, Baker AB: Syndecan-1 regulates vascular smooth muscle cell phenotype. PLoS One, 25;9(2):e89824, Feb 2014. doi: 10.1371/journal.pone.0089824. eCollection 2014. (IF = 3.730).
    

    

24. Das S, Singh G, Baker AB: Overcoming disease-induced growth factor resistance in therapeutic angiogenesis using recombinant co-receptors delivered by a liposomal system. Biomaterials, 35(1):196-205, Jan 2014. doi: 10.1016/j.biomaterials.2013.09.105. Epub 2013 Oct 16. (IF = 8.312).
    

    

25. Voyvodic P, Min D, Liu R, Williams E, Chitalia V, Dunn A, Baker AB: Loss of Syndecan-1 Induces a Pro-Inflammatory Phenotype in Endothelial Cells with a Dysregulated Response to Atheroprotective Flow. Journal of Biological Chemistry, in press DOI: 10.1074/jbc.M113.541573, 2014 (IF = 4.651).
    

    

26. Koskinas K, Chatzizisis Y, Papafaklis M, Coskun A, Baker AB, Jarolim P, Antoniadis A, Edelman E, Stone P, Feldman C: Synergistic Effect of Local Endothelial Shear Stress and Systemic Hypercholesterolemia on Coronary Atherosclerotic Plaque Progression and Composition in Pigs. International Journal of Cardiology, 169(6):394-401, 2013 (IF = 5.509).

    

27. Lee J, Wong M, Smith Q, Baker AB: A Novel System for Studying Mechanical Strain Waveform-Dependent Responses in Vascular Smooth Muscle Cells. Lab on a Chip, 13(23):4573-82, 2013 (IF = 5.697).

    

28. Spruell C, Baker AB: Analysis of a High-Throughput Cone-and-Plate Apparatus for the Application of Defined Spatiotemporal Flow to Cultured Cells. Biotechnology and Bioengineering, 110(6):1782-93, 2013 (IF = 3.946).

    

29. Konstantinos KC, Sukhova GK, Baker AB, Papafaklis MI, Chatzizisis YS, Coskun AU, Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi P, Libby P, Edelman ER, Feldman CL, Stone PH: Thin-Capped Atheromata with Reduced Collagen Content in Pigs develop in Coronary Arterial Regions Exposed to Persistently Low endothelial Shear Stress. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(7):1494-504, 2013 (IF = 6.368).

    

30. Voyvodic P, Min D, Baker AB: A Multichannel Dampened Flow System for Studies on Shear Stress-Mediated Mechanotransduction. Lab on a Chip 12(18):3322-30, 2012 (IF = 6.620).

    

31. Indolfi L, Baker AB, Edelman ER: The Role of Scaffold Microarchitecture in the Regulation of Endothelial Cell-Mediated Immunomodulation. Biomaterials,33(29):7019-27, 2012 (IF = 7.882).

    

32. Baker AB, Gibson W, Kolachalama VB, Golumb M, Indolfi L, Zcharia E, Vlodavsky I, Edelman ER: Heparanase Regulates the Thrombosis in Vascular Injury and Stenting Journal of American College of Cardiology 59(17):1551-60, 2012 (IF = 14.292).

    

33. Jang E, Abawadi H, Watkins M, Edelman ER, Baker AB: Syndecan-4 Proteoliposomes Enhance FGF-2 Induced Proliferation, Migration and Neovascularization of Ischemic Muscle Proceedings of the National Academy of Science USA Jan 31;109(5):1679-84, 2012 (IF = 9.771).

    

34. Franses JW, Baker AB, Chitalia VC, Edelman ER: Stromal Endothelial Cells Directly Regulate Cancer Phenotype. Science: Translational Medicine 3(66):66ra5, 2011 (IF = 3.511).

    

35. Chatzizisis YS*, Baker AB*, Beigel R, Jonas M, M, Coskun AU, Stone BV, Maynard C, Gerrity RG, Feldman CL, Stone PH, and Edelman ER: Upregulation of Extracellular Matrix Degrading Enzymes by Low Endothelial Shear Stress In Vivo Promotes the Formation of Coronary Thin Cap Fibroatheromas. Circulation 123(6):621-30, 2011 (IF = 14.595).

36. Shazly TZ, Baker AB, Naber J, Bon A, Edelman ER: Doping with DOPA enhances the wet adhesion of hydrogel-based surgical sealants. Journal of Biomedical Materials Research A 95(4):1159-69, 2010 (IF = 3.044).

37. Baker AB, Chatzizisis YS, Beigel R, Jonas M, Stone BV, Coskun AU, Maynard C, Rogers C, Feldman CL, Stone PH and Edelman ER: The Role of Heparanase in the Natural History of Atherosclerotic Plaque Development. Atherosclerosis 213(2):436-42, 2010 (IF = 4.086).

38. Konstantinos K, Feldman CL, Chatzizisis YS, Coskun AU, Jonas M, Maynard C, Baker AB, Edelman ER and Stone PH. Natural History of Experimental Coronary Atherosclerosis and Vascular Remodeling In Relation to Endothelial Shear Stress: A Serial, In-Vivo Intravascular Ultrasound Study. Circulation 121(19):2092-101, 2010 (IF = 14.595).

39. Konstantinos K, Chatzizisis YS, Baker AB, Edelman ER, Stone PH and Feldman CL: The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque. Current Opinion in Cardiology 24(6):580-90, 2009 (IF = 2.736).

40. Artzi N, Shazly TZ, Baker AB, Bon A, Edelman ER. Aldehyde-Amine Chemistry Enables Modulated Biosealants with Tissue-Specific Adhesion. Advanced Materials 21, 3399–3403, 2009 (IF = 10.880).

41. Mobine HR, Baker AB, Wang L, Wakimoto H, Jacobsen KC, Seidman CE, Seidman JG, and Edelman ER: Pheochromocytoma-Induced Cardiomyopathy is Modulated by the Synergistic Effects of Cell-Secreted Factors. Circulation: Heart Failure 2:121-128, 2009 (IF = 4.315).

42. Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert P and Edelman ER: Heparanase Alters Arterial Structure, Mechanics and Repair Following Endovascular Stenting in Mice. Circulation Research 104(3):380-7, 2009 (IF = 9.504).

43. Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity RG, Daley W, Edelman ER, Feldman CL, Stone PH: Attenuation of inflammation and expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk coronary atherosclerotic plaques. Atherosclerosis 203(2):387-394, 2009 (IF = 4.086).

44. Baker AB, Ettenson DS, Jonas M, Nugent MA, Iozzo RV, Edelman ER: Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway. Circulation Research 103(3):289-97, 2008 (IF = 9.504).

45. Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, and Roger C: Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Circulation Research 97(7):725-733, 2005 (IF = 9.504).

46. Sanders JE, Baker AB, and Golledge SL: Control of in vivo microvessel ingrowth by modulation of biomaterial local architecture and chemistry. Journal of Biomedical Materials Research 60(1):36-43, 2002 (IF = 3.044).

47. Baker AB and Sanders JE: Angiogenesis stimulated by mechanical loading. Microvascular Research, 60(2):177-181, 2000 (IF = 2.390).

48. Sanders JE, Zachariah SG, Baker AB, Greve JM, and Clinton C: Effects of changes in cadence, prosthetic componentry, and time on interface pressures and shear stresses of three trans-tibial amputees. Clinical Biomechanics, 15(9):684-694, 2000 (IF = 2.036).

49. Gerber MA, Schmidt AJ, Delegard CH, Silvers KL, Baker AB, Gano SR, and Thornton BM. Evaluation of the Magnesium Hydroxide Treatment Process for Stabilizing PFP Plutonium/Nitric Acid Solutions. PNNL-13330, Pacific Northwest National Laboratory, Richland, WA, 2000.

50. Baker AB and Sanders JE. Fluid mechanics analysis of a spring-loaded jet injector. IEEE Transactions on Biomedical Engineering 46(2):235-42, 1999 (IF = 1.782).

51. Sanders JE, Zachariah SG, Greve JM, Baker AB, and Clinton C: Interface mechanics in lower-limb prosthetics: Experimental measurements and finite element modeling. Rehabilitation R&D Progress Reports, pp. 28-29, 1997.

* Authors contributed equally to this work.